What is the catalog number for Perezone?

The catalog number for Perezone is HY-N15582.

What sizes are available for Perezone?

Perezone is available in the following size(s): 1 Each.

Is Perezone in stock?

Perezone is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Perezone?

Perezone is manufactured by QuantiMol.

What is the estimated delivery time for Perezone?

Estimated delivery time for Perezone is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Perezone?

The safety data sheet for Perezone is available here: http://file.medchemexpress.com/batch_PDF/HY-N15582/.

Perezone

Perezone is a sesquiterpenoid benzoquinone found in the roots of Acourtia species. Perezone inhibits the activity of leukemia cell line K-562 and human glioma cell line U-251 (IC50: 6.83 μM) . Perezone increases the expression of caspase 3, 8, and 9 genes associated with apoptosis. Perezone has antioxidant and anti-inflammatory activities[1][2][3][4][5].

Product Specifications

CAS Number

3600-95-1

UNSPSC

12352211

Target

Apoptosis

Related Pathways

Apoptosis

Field of Research

Cancer; Inflammation/Immunology

Smiles

C/C(C)=C\CC[C@H](C1=C(C(C(C)=CC1=O)=O)O)C

Molecular Formula

C15H20O3

Molecular Weight

248.32

References & Citations

[1]Gómez-Serrano G, et al. Time-dependent perezone production in different culture systems of Acourtia cordata[J]. Central European Journal of Biology, 2012, 7: 507-518.|[2]Escobedo-González R G, et al. Characterization and comparison of perezone with some analogues. Experimental and theoretical study[J]. Journal of Molecular Structure, 2015, 1097: 98-105.|[3]Estévez-Carmona MM, et al. Perezone and its phenyl glycine derivative induce cytotoxicity via caspases on human glial cancer cells. Nat Prod Res. 2024 Jun;38 (11) :1823-1833. |[4]Concepción Lozada M, et al. Synthesis, cytotoxic and antioxidant evaluations of amino derivatives from perezone. Bioorg Med Chem. 2012 Sep 1;20 (17) :5077-84.|[5]Martínez J, et al. Computational Characterization of Perezone, Isoperezone and their Sulfur‐Derivatives: Anti‐inflammatory Activity[J]. ChemistrySelect, 2019, 4 (45) : 13333-13346.