Vicanicin

Vicanicin is a depsidone compound found in lichens. Vicanicin inhibits the expression of Hsp70, regulates the redox-sensitive mechanisms within cells, promotes the increase of reactive oxygen species (ROS) in cancer cells, changes the Bax/Bcl-2 ratio, activates caspase-3, and triggers apoptosis. Vicanicin inhibits cell growth and induces apoptosis in androgen-sensitive (LNCaP) and androgen-insensitive (DU-145) human prostate cancer cells. Vicanicin is promising for research of prostate cancer[1].

Product Specifications

CAS Number

[33211-22-2]

UNSPSC

12352005

Target

Apoptosis; Bcl-2 Family; Caspase; HSP; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C1OC2=C(C(C)=C(C(OC)=C2C)Cl)OC3=C1C(C)=C(C(O)=C3C)Cl

Molecular Formula

C18H16Cl2O5

Molecular Weight

383.22

References & Citations

[1]Russo A, et al. Effect of vicanicin and protolichesterinic acid on human prostate cancer cells: role of Hsp70 protein. Chem Biol Interact. 2012 Jan 5;195 (1) :1-10.