Himachalol
Himachalol, a sesquiterpene, is an orally active antispasmodic and anticancer constituent found in the wood of Cedrus deodara. Himachalol has anti-proliferative activity against the melanoma cells, and induces apoptosis (decreases Bcl-2 level and increases Bax level) . Himachalol has systemic hypotension and peripheral vasodilation effect. Himachalol inhibits Carbachol-induced spasm of the intestine. The LD50 of Himachalol in mice is 265 mg/kg (p.o.) and 247 mg/kg (i.p.) [1][2].
Product Specifications
CAS Number
1891-45-8
UNSPSC
12352211
Target
Apoptosis; Bcl-2 Family
Related Pathways
Apoptosis
Smiles
C[C@@]1([C@@]2([H])[C@](C(C)(CCC1)C)([H])C=C(CC2)C)O
Molecular Formula
C15H26O
Molecular Weight
222.37
References & Citations
[1]Shebaby W, et al. Himachalol induces apoptosis in B16-F10 murine melanoma cells and protects against skin carcinogenesis. J Ethnopharmacol. 2020 May 10;253:112545. |[2]Kar K, et al. Spasmolytic constituents of Cedrus deodara (Roxb.) Loud: pharmacological evaluation of himachalol. J Pharm Sci. 1975 Feb;64 (2) :258-262.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
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