Zaluzanin C

Zaluzanin C is a sesquiterpene lactone. Zaluzanin C has anti-inflammatory activity and can inhibit the production of mtROS, block the NF-κB signaling pathway, and reduce the production of TNF-α. In addition, Zaluzanin C can inhibit the differentiation of 3T3-L1 preadipocytes into mature adipocytes[1][2][3].

Product Specifications

CAS Number

[16838-87-2]

UNSPSC

12352005

Target

NF-κB; PPAR; Reactive Oxygen Species (ROS)

Related Pathways

Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Vitamin D Related/Nuclear Receptor

Field of Research

Inflammation/Immunology

Smiles

C=C1[C@]2([H])[C@]3([H])[C@](CCC([C@]2([H])C[C@@H]1O)=C)([H])C(C(O3)=O)=C

Molecular Formula

C15H18O3

Molecular Weight

246.30

References & Citations

[1]Valkute TR, et al. Synthesis and anticancer studies of Michael adducts and Heck arylation products of sesquiterpene lactones, zaluzanin D and zaluzanin C from Vernonia arborea. RSC Adv. 2018 Nov 14;8 (67) :38289-38304.|[2]Kwak SH, et al. Zaluzanin C Inhibits Differentiation of 3T3-L1 Preadipocytes into Mature Adipocytes. J Obes Metab Syndr. 2019 Jun;28 (2) :105-111.|[3]Jung JW, et al. Zaluzanin C Alleviates Inflammation and Lipid Accumulation in Kupffer Cells and Hepatocytes by Regulating Mitochondrial ROS. Molecules. 2023 Nov 8;28 (22) :7484.