Chaetoglobosin E

Chaetoglobosin E is a Ferroptosis inducer that exhibits significant cytotoxicity against human tumor cell lines MDA-MB231 and A549, with IC50 values of 9.14 and 7.47 μM, respectively. By downregulating the expression of GPX4 in A549 cells, Chaetoglobosin E markedly increases intracellular levels of Fe2+ and the lipid peroxidation product malondialdehyde (MDA), leading to mitochondrial shrinkage, reduction or disappearance of cristae, and subsequent induction of ferroptosis. Chaetoglobosin E can be used for research in the field of cancer[1].

Product Specifications

CAS Number

[55945-74-9]

UNSPSC

12352005

Target

Ferroptosis

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

CC1=C(C)[C@]([C@@H](N2)CC3=CNC4=C3C=CC=C4)([H])[C@@]([C@](/C=C/C[C@H](C)/C=C5\C)([H])[C@@H]1O)(C(CC[C@H](O)C5=O)=O)C2=O

Molecular Formula

C32H38N2O5

Molecular Weight

530.65

References & Citations

[1]Wang YY, et al. Unusual chaetoglobosins and a new type of ferroptosis inducer from an endophytic fungus Chaetomium sp. UJN-EF006. Bioorg Chem. 2025 May;158:108342.