4,4′-Secalonic acid D
4,4′-Secalonic acid D (Compound 12) is a PARP1 inhibitor. 4,4′-Secalonic acid D induces the accumulation of ROS and DNA damage, activates the caspase-3/GSDME pathway, and triggers apoptosis and pyroptosis of tumor cells by inhibiting PARP1. 4,4′-Secalonic acid D has anti-tumor activity[1].
Product Specifications
CAS Number
2265910-52-7
UNSPSC
12352005
Target
Apoptosis; Caspase; PARP; Pyroptosis; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer
Smiles
O[C@H]1[C@](C2=C(O)C[C@@H]1C)(C(OC)=O)OC3=C(C4=C(O[C@]5(C(OC)=O)C(C6=O)=C(O)C[C@H](C)[C@H]5O)C6=C(O)C=C4)C=CC(O)=C3C2=O
Molecular Formula
C32H30O14
Molecular Weight
638.57
References & Citations
[1]Zhang MK, et al. Structurally diverse tetrahydroxanthone analogues from Paraconiothyrium sp. AC31 with pyroptosis induction through targeted inhibition of PARP1 in hepatocellular carcinoma cells. Bioorg Chem. 2025 Feb 26;157:108310.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LC401018 20 µg
PSP (REG1A) (NM_002909) Human Over-expression Lysate
Sign In for Pricing
View Details 
