Antcin B

Antcin B is a SARS-CoV-2 3-chymotrypsin-like protease (3CL Pro) inhibitor. Antcin B binds to multiple key amino acid residues of 3CL Pro (such as Leu141, Asn142, Glu166, His163, etc.) through hydrogen bonds, salt bridges, and hydrophobic interactions, thereby inhibiting the activity of 3CL Pro, blocking the cleavage process of viral polyproteins, and suppressing the replication of the SARS-CoV-2 virus in host cells. Antcin B is promising for research of COVID-19[1].

Product Specifications

CAS Number

[163597-25-9]

UNSPSC

12352211

Target

SARS-CoV; Virus Protease

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Smiles

C[C@@]12C3=C(C(C[C@@]1([H])[C@@H](C(CC2)=O)C)=O)[C@@]4([H])[C@](CC3=O)([C@@](CC4)([H])[C@H](C)CCC(C(C)C(O)=O)=C)C

Molecular Formula

C29H40O5

Molecular Weight

468.62

References & Citations

[1]Dakpa G, et al. Antcin-B, a phytosterol-like compound from Taiwanofungus camphoratus inhibits SARS-CoV-2 3-chymotrypsin-like protease (3CLPro) activity in silico and in vitro. Sci Rep. 2023 Oct 10;13 (1) :17106.