Hyrtiosal
Hyrtiosal, found in the marine sponge Hyrtios erectus, is an inhibitor of the N-terminal domain (NTD) of HIV-1 integrase (HIV-1 IN) with an IC50 value of 9.60-0.86 μM. Hyrtiosal binds to the Ser17, Trp19, and Lys34 sites on the NTD of HIV-1 IN, inhibiting the binding of HIV-1 viral DNA to integrase and interfering with the formation of the pre-integrated complex of HIV-1. Hyrtiosal is promising for research of anti-HIV agents[1].
Product Specifications
CAS Number
138355-07-4
UNSPSC
12352005
Target
HIV; HIV Integrase
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection
Smiles
C[C@]12[C@@](C[C@@](C)([C@H]2C[C@@H](C3=COC=C3)O)C=O)([H])[C@@]4([C@@](C(C)(CCC4)C)([H])CC1)C
Molecular Formula
C25H38O3
Molecular Weight
386.57
References & Citations
[1]Du L, et al. Hyrtiosal, from the marine sponge Hyrtios erectus, inhibits HIV-1 integrase binding to viral DNA by a new inhibitor binding site. ChemMedChem. 2008 Jan;3 (1) :173-80.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
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