Eupolauridine
Eupolauridine (Canangine) is a selective DNA topoisomerase II inhibitor with IC50 values of 20 μM for fungal topoisomerase I and 33 μM for human topoisomerase I. Eupolauridine exerts antifungal activity by inhibiting the catalytic activity of topoisomerase II and stabilizing its cleavage complex with DNA, leading to DNA damage. Eupolauridine is promising for research of fungal infectious diseases[1][2].
Product Specifications
CAS Number
[58786-39-3]
Product Name Alternative
Canangine
UNSPSC
12352005
Target
Fungal; Topoisomerase
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Smiles
C1(C2=CC=CC=C23)=NC=CC4=C1C3=NC=C4
Molecular Formula
C14H8N2
Molecular Weight
204.23
References & Citations
[1]Khan SI, et al. Antifungal activity of eupolauridine and its action on DNA topoisomerases. Antimicrob Agents Chemother. 2002 Jun;46 (6) :1785-92.|[2]Lavanya M, et al. Synthesis and Anticancer Properties of Functionalized 1,6-Naphthyridines. Top Curr Chem (Cham) . 2021 Feb 24;379 (2) :13.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Topo I; Topo II
Curated Selection
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