Isotenulin
Isotenulin inhibits the efflux function of P-glycoprotein by stimulation of P-glycoprotein ATPase, thereby overcoming the multidrug resistance (MDR) of cancer cells. Isotenulin exhibits cytotoxicity in multidrug-resistant cancer cell KB-vin and sensitive cancer cell HeLaS3. Isotenulin exhibits synergistic effect with Paclitaxel , Vinblastine (HY-13780) and Doxorubicin (HY-15142).
Product Specifications
CAS Number
10092-04-3
UNSPSC
12352005
Target
P-glycoprotein
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cancer
Smiles
CC(O[C@H]1[C@]2([C@](C=CC2=O)([H])[C@@H](C[C@@]3([H])[C@@]1([H])[C@H](C(O3)=O)C)C)C)=O
Molecular Formula
C17H22O5
Molecular Weight
306.35
References & Citations
[1]Chang YT, et al., Tenulin and isotenulin inhibit P-glycoprotein function and overcome multidrug resistance in cancer cells. Phytomedicine. 2019 Feb;53:252-262.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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