Isotenulin

Isotenulin inhibits the efflux function of P-glycoprotein by stimulation of P-glycoprotein ATPase, thereby overcoming the multidrug resistance (MDR) of cancer cells. Isotenulin exhibits cytotoxicity in multidrug-resistant cancer cell KB-vin and sensitive cancer cell HeLaS3. Isotenulin exhibits synergistic effect with Paclitaxel (HY-B0015), Vinblastine (HY-13780) and Doxorubicin (HY-15142) [1].

Product Specifications

CAS Number

[10092-04-3]

UNSPSC

12352005

Target

P-glycoprotein

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Cancer

Smiles

CC(O[C@H]1[C@]2([C@](C=CC2=O)([H])[C@@H](C[C@@]3([H])[C@@]1([H])[C@H](C(O3)=O)C)C)C)=O

Molecular Formula

C17H22O5

Molecular Weight

306.35

References & Citations

[1]Chang YT, et al., Tenulin and isotenulin inhibit P-glycoprotein function and overcome multidrug resistance in cancer cells. Phytomedicine. 2019 Feb;53:252-262.