Azaspirene
Azaspirene ((-) -Azaspirene) is an angiogenesis and Raf-1 activation inhibitor isolated from the fungus Neosartorya sp. Azaspirene inhibits vascular endothelial growth factor (VEGF) -induced human umbilical vein endothelial cell (HUVEC) migration and Raf-1 activation, but has no effect on the activation of kinase insert domain-containing receptor/fetal liver kinase 1 (VEGF receptor 2) [1].
Product Specifications
CAS Number
[461644-34-8]
Product Name Alternative
(-) -Azaspirene
UNSPSC
12352005
Target
Raf; VEGFR
Related Pathways
MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O[C@@H]1[C@]2(C(N[C@@]1(O)CC3=CC=CC=C3)=O)OC(/C=C/C=C/CC)=C(C2=O)C
Molecular Formula
C21H23NO5
Molecular Weight
369.41
References & Citations
[1]Asami Y, et al. Azaspirene, a fungal product, inhibits angiogenesis by blocking Raf-1 activation. Cancer Sci. 2008 Sep;99 (9) :1853-8.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
Lentiviral mouse Tbx19 shRNA (UAS) - Lentiviral mouse Tbx19 shRNA (UAS) (25)
TM173, CT (TMEM173, ERIS, MITA, STING, Transmembrane protein 173, Endoplasmic reticulum interferon stimulator, Mediator of IRF3 activation, Stimulator of interferon genes protein) (MaxLight 405) discontinued
