Butyrolactone Ia

Butyrolactone Ia is the inhibitor for the NO production with an IC50 of 18 μM. Butyrolactone Ia inhibits LPS (HY-D1056) -induced mRNA expression of iNOS and the inflammatory cytokine IL-1β. Butyrolactone Ia modulates autophagy in HeLa cells, and exhibits immune suppressive activity[1].

Product Specifications

CAS Number

[942986-92-7]

UNSPSC

12352005

Target

Autophagy; Interleukin Related; NO Synthase

Related Pathways

Autophagy; Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Inflammation/Immunology

Smiles

OC([C@]1(C(C2=CC=C(C=C2)O)=C(C(O1)=O)O)CC3=CC(C/C=C(C)\C)=C(C=C3)O)=O

Molecular Formula

C23H22O7

Molecular Weight

410.42

References & Citations

[1]Ujie Y, et al., Aspergillus terreus IFM 65899-THP-1 cells interaction triggers production of the natural product butyrolactone Ia, an immune suppressive compound. Sci Rep. 2024 Nov 16;14 (1) :28278.