Butyrolactone Ia
Butyrolactone Ia is the inhibitor for the NO production with an IC50 of 18 μM. Butyrolactone Ia inhibits LPS (HY-D1056) -induced mRNA expression of iNOS and the inflammatory cytokine IL-1β. Butyrolactone Ia modulates autophagy in HeLa cells, and exhibits immune suppressive activity[1].
Product Specifications
CAS Number
[942986-92-7]
UNSPSC
12352005
Target
Autophagy; Interleukin Related; NO Synthase
Related Pathways
Autophagy; Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Inflammation/Immunology
Smiles
OC([C@]1(C(C2=CC=C(C=C2)O)=C(C(O1)=O)O)CC3=CC(C/C=C(C)\C)=C(C=C3)O)=O
Molecular Formula
C23H22O7
Molecular Weight
410.42
References & Citations
[1]Ujie Y, et al., Aspergillus terreus IFM 65899-THP-1 cells interaction triggers production of the natural product butyrolactone Ia, an immune suppressive compound. Sci Rep. 2024 Nov 16;14 (1) :28278.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Curated Selection
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