Inostamycin A (sodium)
Inostamycin A sodium is an antibiotic, which can be found in Streptomyces sp. MH816-AF15. Inostamycin A sodium blocks the phosphatidylinositol turnover, exhibits antimicrobial and cytotoxic activities through inhibition of CDP-DG:inositol transferase. Inostamycin A sodium is promising for research of cancers[1][2][3].
Product Specifications
UNSPSC
12352211
Target
Antibiotic
Related Pathways
Anti-infection
Field of Research
Cancer
Smiles
O[C@@]1([C@]2(O[C@]([C@H](C2)C)([H])[C@@H](CC)C([C@@H](C)[C@@H](O)[C@@H]([C@]3([H])[C@H]([C@H]([C@@H]([C@@](O)(O3)[C@@H](CC)C(O[Na])=O)C)O)CC)C)=O)C)O[C@](CC)(C[C@H]1C)[C@@H](O)CCC
Molecular Formula
C38H67NaO11
Molecular Weight
722.92
References & Citations
[1]Baba Y, et al. Inostamycin, an inhibitor of cytidine 5'-diphosphate 1,2-diacyl-sn-glycerol (CDP-DG) : inositol transferase, suppresses invasion ability by reducing productions of matrix metalloproteinase-2 and -9 and cell motility in HSC-4 tongue carcinoma cell line. Clin Exp Metastasis. 2000;18 (3) :273-9.|[2]Imoto M, et al. Isolation and structure determination of inostamycin, a novel inhibitor of phosphatidylinositol turnover[J]. Journal of Natural Products, 1990, 53 (4) : 825-829.|[3]Yu G, et al. The Total Synthesis of Inostamycin A. Angew Chem Int Ed Engl. 2016 Feb 12;55 (7) :2573-6.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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