Arphamenine B

Arphamenine B is a Zn2+-dependent exopeptidase that selectively removes arginine and/or lysine residues from the NH2-terminus of several peptide substrates. Arphamenine B is an inhibitor of aminopeptidase B that can be isolated from bacteria. Arphamenine B enhances the immune response and is used to characterize novel proteases[1][2][3].

Product Specifications

CAS Number

[88465-81-0]

UNSPSC

12352005

Target

Bacterial

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

N=C(N)NCCC[C@H](N)C(C[C@H](C(O)=O)CC1=CC=C(C=C1)O)=O.Cl

Molecular Formula

C16H25ClN4O4

Molecular Weight

372.85

References & Citations

[1]Foulon T, et al. Aminopeptidase B (EC 3.4.11.6) . Int J Biochem Cell Biol. 1999 Jul;31 (7) :747-50.|[2]Umezawa H, et al. Arphamenines A and B, new inhibitors of aminopeptidase B, produced by bacteria. J Antibiot (Tokyo) . 1983 Nov;36 (11) :1572-5.|[3]Kubo H, et al. Involvement of sperm proteases in the binding of sperm to the vitelline envelope in Xenopus laevis. Zoolog Sci. 2008 Jan;25 (1) :80-7.