Propeptin

Propeptin is a peptide antibiotic composed of 19 amino acids. Propeptin has weaker activity against Pseudomonas aeruginosa, Mycobacterium monobacterium, and Xanthomonas oryzae. Propeptin has no effect on KB and L1210 cells of tumor cell lines, but has an inhibitory effect on prolyl endopeptidase[1].

Product Specifications

CAS Number

[146764-30-9]

UNSPSC

12352005

Target

Antibiotic; Bacterial

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Smiles

O=C([C@@]1([H])N(CCC1)C([C@@H](NC(CNC(C[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC2=O)CC3=CNC4=CC=CC=C34)=O)CC(O)=O)=O)CC5=CC=C(C=C5)O)=O)CCCNC(N)=N)=O)C(N[C@@H](CC(C)C)C(N[C@H](C(NCC(NCC(N[C@H](C(N[C@@H]([C@H](O)C)C(N[C@H](C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CO)C(N6[C@@H](CCC6)C(O)=O)=O)=O)=O)CC7=CC=CC=C7)=O)=O)CC8=CN=CN8)=O)=O)=O)CC9=CC=CC=C9)=O)=O)=O)=O)CC%10=CC=C(C=C%10)O)=O)N[C@H]2CC%11=CNC%12=CC=CC=C%11%12

Molecular Formula

C113H142N26O27

Molecular Weight

2296.49

References & Citations

[1]Ken-ichi Kimura, et al. Novel propeptin analog, propeptin-2, missing two amino acid residues from the propeptin C-terminus loses antibiotic potency. J Antibiot (Tokyo) . 2007 Aug;60 (8) :519-23.