Phleomycin E

Phleomycin E is a heteropeptide antibiotic. Phleomycin E has anti-Gram-positive bacteria, negative bacteria and mycobacterium effects. Phleomycin E extends the survival time of mice transplanted with Ehrman's ascites cancer. Phleomycin E inhibits airy entity carcinoma in mice with an IC50 of 0.31 μg/mL[1].

Product Specifications

CAS Number

[11031-13-3]

UNSPSC

12352005

Target

Antibiotic; Bacterial

Related Pathways

Anti-infection

Field of Research

Cancer; Infection

Smiles

O=C(N)OC1C(C(OC2C(OC(C(C2O)O)CO)OC(C(C(NC(C(C(C)C(NC(C(C)O)C(NCCC3=NC(CS3)C4=NC(C(NCCCCNC(NCCCCNC(N)=N)=N)=O)=CS4)=O)=O)O)C)=O)NC(C5=NC(C(CC(N)=O)NCC(C(N)=O)N)=NC(N)=C5C)=O)C6=CN=CN6)OC(C1O)CO)O

Molecular Formula

C60H97N23O21S2

Molecular Weight

1540.68

References & Citations

[1]R M Hall, et al. Identification and mapping of regions of the plasmid pKM101 which influence the growth rate and resistance to phleomycin E of Escherichia coli WP2. J Bacteriol. 1985 Sep;163 (3) :1142-6.