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Pochonin D

Pochonin D ((+) -Pochonin D) is an inhibitor of heat shock protein 90 (Hsp90) with antiviral and anti-inflammatory activities. Pochonin D inhibits Hsp90, affecting the homeostasis, folding, and assembly processes of viral proteins, reducing the replication ability of the virus. Pochonin D reduces the infiltration of inflammatory cells and the secretion of inflammatory cytokines such as TNF-α and IL-1β, alleviating the inflammatory response. Pochonin D is promising for research of Human rhinoviruses (HRV) infections and cancers[1].

Product Specifications

CAS Number

544712-82-5

Product Name Alternative

(+) -Pochonin D

UNSPSC

12352101

Target

Enterovirus; HSP; Interleukin Related

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection; Inflammation/Immunology

Smiles

ClC1=C2C(C(O[C@@H](C/C=C/CC/C=C/C(C2)=O)C)=O)=C(C=C1O)O

Molecular Formula

C18H19ClO5

Molecular Weight

350.79

References & Citations

[1]Song JH, et al. Antiviral and Anti-Inflammatory Activities of Pochonin D, a Heat Shock Protein 90 Inhibitor, against Rhinovirus Infection. Biomol Ther (Seoul) . 2018 Nov 1;26 (6) :576-583.

Shipping Conditions

Room temperature

Scientific Category

Natural Products

Clinical Information

No Development Reported

Frequently Asked Questions

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