2-Hydroxyaclacinomycin A
2-Hydroxyaclacinomycin A is an anthracycline antibiotic. 2-Hydroxyaclacinomycin A has the activity of inhibiting leukemia L-1210 cells, and the IC50 for RNA and DNA synthesis is 0.10 μg/mL and 0.95 μg/mL, respectively[1].
Product Specifications
CAS Number
[79127-36-9]
UNSPSC
12352005
Target
Antibiotic; Bacterial; DNA/RNA Synthesis
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Field of Research
Cancer; Infection
Smiles
O=C1C2=C(C(O)=CC(O)=C2)C(C3=C1C=C(C4=C3O)[C@@H](C(OC)=O)[C@@](O)(CC)C[C@@H]4O[C@@H]5O[C@H]([C@H]([C@H](C5)N(C)C)O[C@@H]6O[C@H]([C@H]([C@H](C6)O)O[C@@H]7O[C@H](C(CC7)=O)C)C)C)=O
Molecular Formula
C42H53NO16
Molecular Weight
827.87
References & Citations
[1]Y Matsuzawa, et al. Reduction and hydrolysis of 2-hydroxyaclacinomycin A. J Antibiot (Tokyo) . 1981 Nov;34 (11) :1495-7.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Curated Selection
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