Gypsetin

Gypsetin can inhibit acylcoenzyme A, cholesterol acyltransferase (ACAT) activity, inhibit rat liver microbody ACAT with an IC50 of 18 μM, and its action is competitive with oleoyl-COA substrate, Ki value is 5.5 μM. Gypsetin also inhibits Oleic acid from forming cholesterol esters with an IC50 of 0.65 μM[1].

Product Specifications

CAS Number

[155114-38-8]

UNSPSC

12352005

Target

Acyltransferase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Smiles

C=CC(C)([C@]12[C@](C3=CC=CC=C3N1)(C[C@]4([H])N2C([C@@]5([H])N([C@@]6([C@](C5)(C7=CC=CC=C7N6)O)C(C)(C)C=C)C4=O)=O)O)C

Molecular Formula

C32H36N4O4

Molecular Weight

540.65

References & Citations

[1]B Nuber, et al. Gypsetin, a new inhibitor of acyl-CoA: cholesterol acyltransferase produced by Nannizzia gypsea var. incurvata IFO 9228. II. Structure determination. J Antibiot (Tokyo) . 1994 Feb;47 (2) :168-72.