Hedamycin

Hedamycin is a quinone antibiotic. Hedamycin has anti-Gram-positive bacteria, negative bacterium, mycobacterium and yeast fungus activity (MIC is 0.031-3.2 μg/mL) . 0.8 μg/mL of Hedamycin can inhibit Tetrahymena pyriformis. Hedamycin also can inhibit rat duodenum adenocarcinoma, rats Walker 256 tumor (50 μg/kg/day), HeLa cell (IG50 is 0.00013 μg/mL), e. coli lysogenic W1709 (λ) phage (MIC is 0.0125 μg/mL) [1].

Product Specifications

CAS Number

[11048-97-8]

UNSPSC

12352005

Target

Antibiotic; Bacterial

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

[H][C@@]1(O[C@H]1C)[C@@]2(O[C@]2(C3=CC(C4=C(C5=C(C(C6=C(C(O)=C(C=C6[C@H]7C[C@H]([C@@H]([C@H](O7)C)O)N(C)C)[C@H]8C[C@](N(C)C)([C@@H]([C@@H](O8)C)O)C)C5=O)=O)C=C4C)O3)=O)C)[H]

Molecular Formula

C41H50N2O11

Molecular Weight

746.84

References & Citations

[1]Lan Chun Tu, et al. Hedamycin, a DNA alkylator, induces (gamma) H2AX and chromosome aberrations: involvement of phosphatidylinositol 3-kinase-related kinases and DNA replication fork movement. Mol Cancer Ther. 2005 Aug;4 (8) :1175-85.