Hedamycin
Hedamycin is a quinone antibiotic. Hedamycin has anti-Gram-positive bacteria, negative bacterium, mycobacterium and yeast fungus activity (MIC is 0.031-3.2 μg/mL) . 0.8 μg/mL of Hedamycin can inhibit Tetrahymena pyriformis. Hedamycin also can inhibit rat duodenum adenocarcinoma, rats Walker 256 tumor (50 μg/kg/day), HeLa cell (IG50 is 0.00013 μg/mL), e. coli lysogenic W1709 (λ) phage (MIC is 0.0125 μg/mL) [1].
Product Specifications
CAS Number
11048-97-8
UNSPSC
12352005
Target
Antibiotic; Bacterial
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
[H][C@@]1(O[C@H]1C)[C@@]2(O[C@]2(C3=CC(C4=C(C5=C(C(C6=C(C(O)=C(C=C6[C@H]7C[C@H]([C@@H]([C@H](O7)C)O)N(C)C)[C@H]8C[C@](N(C)C)([C@@H]([C@@H](O8)C)O)C)C5=O)=O)C=C4C)O3)=O)C)[H]
Molecular Formula
C41H50N2O11
Molecular Weight
746.84
References & Citations
[1]Lan Chun Tu, et al. Hedamycin, a DNA alkylator, induces (gamma) H2AX and chromosome aberrations: involvement of phosphatidylinositol 3-kinase-related kinases and DNA replication fork movement. Mol Cancer Ther. 2005 Aug;4 (8) :1175-85.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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