Paeciloquinone A
Paeciloquinone A can inhibit EGFR protein tyrosine kinase. Paeciloquinone A inhibits the V-abl protein tyrosine kinase with an IC50 of 0.59 μM[1].
Product Specifications
CAS Number
[162797-33-3]
UNSPSC
12352005
Target
EGFR
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Infection
Smiles
O=C1C2=C(C(C3=C(C(C4C(OCC4)=O)=C(C=C13)O)O)=O)C(O)=CC(O)=C2
Molecular Formula
C18H12O8
Molecular Weight
356.28
References & Citations
[1]F Petersen, et al. Paeciloquinones A, B, C, D, E and F: new potent inhibitors of protein tyrosine kinases produced by Paecilomyces carneus. I. Taxonomy, fermentation, isolation and biological activity. J Antibiot (Tokyo) . 1995 Mar;48 (3) :191-8.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Curated Selection
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