Asterriquinone

Asterriquinone (ARQ), a Asterriquinone analog, is a Grb-2 binding inhibitor. Asterriquinone inhibits the Grb-2 binding activity to tyrosine phosphorylated EGFR, with an IC50 of 8.37 μM. Asterriquinone is a HIV1 reverse transcriptase inhibitor with a Ki of 2.3 μM. Asterriquinone also inhibits Grb-7 and PLC-γ binding activities.[1][2].

Product Specifications

CAS Number

[60696-52-8]

Product Name Alternative

ARQ; Asterriquinone SU5504

UNSPSC

12352005

Target

EGFR; HIV; Reverse Transcriptase

Related Pathways

Anti-infection; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection

Smiles

O=C1C(O)=C(C2=CN(C(C)(C)C=C)C3=C2C=CC=C3)C(C(O)=C1C4=CN(C(C)(C)C=C)C5=C4C=CC=C5)=O

Molecular Formula

C32H30N2O4

Molecular Weight

506.59

References & Citations

[1]Alvi KA, et al. Asterriquinones produced by Aspergillus candidus inhibit binding of the Grb-2 adapter to phosphorylated EGF receptor tyrosine kinase. J Antibiot (Tokyo) . 1999 Mar;52 (3) :215-23.|[2]Ono K, et al. Inhibition of HIV-reverse transcriptase activity by asterriquinone and its analogues. Biochem Biophys Res Commun. 1991 Jan 15;174 (1) :56-62.