Asterriquinone
Asterriquinone (ARQ), a Asterriquinone analog, is a Grb-2 binding inhibitor. Asterriquinone inhibits the Grb-2 binding activity to tyrosine phosphorylated EGFR, with an IC50 of 8.37 μM. Asterriquinone is a HIV1 reverse transcriptase inhibitor with a Ki of 2.3 μM. Asterriquinone also inhibits Grb-7 and PLC-γ binding activities.[1][2].
Product Specifications
CAS Number
60696-52-8
Product Name Alternative
ARQ; Asterriquinone SU5504
UNSPSC
12352005
Target
EGFR; HIV; Reverse Transcriptase
Related Pathways
Anti-infection; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Smiles
O=C1C(O)=C(C2=CN(C(C)(C)C=C)C3=C2C=CC=C3)C(C(O)=C1C4=CN(C(C)(C)C=C)C5=C4C=CC=C5)=O
Molecular Formula
C32H30N2O4
Molecular Weight
506.59
References & Citations
[1]Alvi KA, et al. Asterriquinones produced by Aspergillus candidus inhibit binding of the Grb-2 adapter to phosphorylated EGF receptor tyrosine kinase. J Antibiot (Tokyo) . 1999 Mar;52 (3) :215-23.|[2]Ono K, et al. Inhibition of HIV-reverse transcriptase activity by asterriquinone and its analogues. Biochem Biophys Res Commun. 1991 Jan 15;174 (1) :56-62.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
Phase 3
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