Manumycin E

Manumycin E has anti-Gram-positive bacteria and Escherichia coli effects, but the effect is very weak against other anti-Gram-negative bacteria, and has no effect on fungi. Manumycin E inhibits RAS Faraday base transfer and has weak cytotoxic activity against human cloned cancer cell lines HCT-116 (IC50 is 15.6 μg/mL) [1].

Product Specifications

CAS Number

[156250-43-0]

UNSPSC

12352211

Target

Bacterial

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

O=C1C(NC(/C=C/C=C/C=C/[C@]2([C@@]3([H])[C@](C(C(NC(/C=C/C=C/C=C/CCC(C)C)=O)=C2)=O)([H])O3)O)=O)=C(O)CC1

Molecular Formula

C30H34N2O7

Molecular Weight

534.60

References & Citations

[1]Y Z Shu, et al. Manumycins E, F and G, new members of manumycin class antibiotics, from Streptomyces sp. J Antibiot (Tokyo) . 1994 Mar;47 (3) :324-33.