Madindoline A
Madindoline A is an IL-6 inhibitor. Madindoline A inhibits IL-6-dependent MH-60 cells and has no inhibitory effect on IL-6-independent MH-60 cells. In the presence of 0.1 U/mL IL-6, it inhibits IL-6-dependent MH-60 cells with an IC50 of 8 μM. Madindoline A has no antimicrobial effect[1].
Product Specifications
CAS Number
[184877-64-3]
UNSPSC
12352211
Target
Interleukin Related
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Smiles
O[C@@](C1=CC=CC=C12)(CCO3)[C@@]3([H])N2C[C@]4(C(C(CCCC)=C(C4=O)C)=O)C
Molecular Formula
C22H27NO4
Molecular Weight
369.45
References & Citations
[1]Ramandeep Kaur, et al. Diversity-Oriented Synthetic Approaches for Furoindoline: A Review. Curr Org Synth. 2019;16 (3) :342-368.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Curated Selection
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