Hibarimicin B
Hibarimicin B (Angelmicin B) is a tyrosine kinase inhibitor. It selectively inhibits the activity of src tyrosine kinase without affecting protein kinase A and C. It also has moderate anti-Gram-positive bacteria activity with a MIC of 0.8-12.56 μg/mL[1].
Product Specifications
CAS Number
151687-86-4
Product Name Alternative
Angelmicin B
UNSPSC
12352005
Target
Bacterial; Src
Related Pathways
Anti-infection; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Smiles
[H]C1([C@@](C2=C(C3=C(C(O)=C2C4=O)C(C(C(C(O)=C56)=C(OC)C(OC)=C6C=C7C[C@]8([C@H]([C@@H]([C@H]([C@](CCC)([C@](O)8C(C7=C5O)=O)O)O[C@H]9CC[C@@H]([C@H](O9)C)O[C@H]%10CC[C@@](C(C)=O)([C@@H](O%10)C)O)O)O[C@H]%11O[C@@H]([C@H]([C@H](C%11)O)O)C)[H])=C(C3=O)OC)=O)O)(O[C@]%12(CCC)[C@@]41O)[H])[C@@H](O[C@H]%13O[C@@H]([C@H]([C@H](C%13)O)O)C)[C@H](O)[C@H]%12O[C@H]%14CC[C@@H]([C@H](O%14)C)O[C@H]%15CC[C@@](C(C)=O)([C@@H](O%15)C)O
Molecular Formula
C85H112O37
Molecular Weight
1725.78
References & Citations
[1]Sridhar Narayan, et al. Studies toward the total synthesis of angelmicin B (hibarimicin B) : synthesis of a model CD-D' arylnaphthoquinone. Org Lett. 2004 Oct 14;6 (21) :3789-92.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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