Hibarimicin A
Hibarimicin A is a tyrosine kinase inhibitor found in Microbispora rosea subsp. hibaria. Hibarimicin A selectively inhibits the activity of src tyrosine kinase without affecting protein kinase A and C. Hibarimicin A also has moderate anti-Gram-positive bacteria activity with a MIC of 0.8-12.56 μg/mL[1].
Product Specifications
CAS Number
208588-76-5
UNSPSC
12352211
Target
Bacterial; Src
Related Pathways
Anti-infection; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Smiles
CCCC12C3(C(C(C(C2O[C@@H]4O[C@@H]([C@H](CC4)O[C@H]5O[C@H](C(O)(CC5)C(C)=O)C)C)O)O[C@H]6C[C@H]([C@H]([C@@H](O6)C)O)O)([H])C(C7=C(O)C(C(C(OC)=C(C8=C(C(OC)=C9C(C(O)=C%10C(CC%11([H])C(C%10=O)(C(O)(C(C(C%11O[C@H]%12C[C@H]([C@H]([C@@H](O%12)C)O)O)O)O[C@@H]%13O[C@@H]([C@H](CC%13)O[C@@H]%14O[C@H]([C@@](O)(CC%14)C(C)=O)C)C)CCC)O)=C9)=C8O)OC)C%15=O)=O)=C%15C(O)=C7C3=O)([H])O1)O
Molecular Formula
C85H112O37
Molecular Weight
1725.78
References & Citations
[1]Sridhar Narayan, et al. Studies toward the total synthesis of angelmicin B (hibarimicin B) : synthesis of a model CD-D' arylnaphthoquinone. Org Lett. 2004 Oct 14;6 (21) :3789-92.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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