Compound E

Compound E is a γ-secretase inhibitor. Compound E blocks β-amyloid (40), β-amyloid (42), and Notch γ-secretase cleavage with IC50s of 0.24, 0.37, 0.32 nM, respectively.

Product Specifications

CAS Number

[209986-17-4]

Product Name Alternative

γ-Secretase-IN-1

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

γ-secretase

Type

Reference compound

Related Pathways

Neuronal Signaling; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Compound_E.html

Purity

99.97

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC1=CC(CC(N[C@@H](C)C(N[C@@H]2C(N(C)C(C=CC=C3)=C3C(C4=CC=CC=C4)=N2)=O)=O)=O)=CC(F)=C1

Molecular Formula

C27H24F2N4O3

Molecular Weight

490.50

Precautions

H302, H315, H319, H335

References & Citations

[1]Beher D, et al. Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology. J Biol Chem. 2001 Nov 30;276 (48) :45394-402.|[2]Rasul S, et al. Inhibition of gamma-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells. Br J Cancer. 2009 Jun 16;100 (12) :1879-88.