Compound E
Compound E is a γ-secretase inhibitor. Compound E blocks β-amyloid (40), β-amyloid (42), and Notch γ-secretase cleavage with IC50s of 0.24, 0.37, 0.32 nM, respectively.
Product Specifications
CAS Number
209986-17-4
Product Name Alternative
γ-Secretase-IN-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
γ-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Compound_E.html
Purity
99.97
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC1=CC(CC(N[C@@H](C)C(N[C@@H]2C(N(C)C(C=CC=C3)=C3C(C4=CC=CC=C4)=N2)=O)=O)=O)=CC(F)=C1
Molecular Formula
C27H24F2N4O3
Molecular Weight
490.50
Precautions
H302, H315, H319, H335
References & Citations
[1]Beher D, et al. Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology. J Biol Chem. 2001 Nov 30;276 (48) :45394-402.|[2]Rasul S, et al. Inhibition of gamma-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells. Br J Cancer. 2009 Jun 16;100 (12) :1879-88.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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