Argyrin F
Argyrin F a cyclic peptide with antitumoral activities. Argyrin F inhibits cell proliferation, migration, invasion and colony formation by partial induction of apoptosis and epithelial-mesenchymal transition (EMT) . Argyrin F stabilizes p27kip, up-regulated p21waf1/cip1 and depletes COX2. Argyrin F can be used for the study of pancreatic ductal adenocarcinoma (PDAC) [1].
Product Specifications
CAS Number
[444300-74-7]
UNSPSC
12352005
Target
Apoptosis
Related Pathways
Apoptosis
Field of Research
Cancer
Smiles
COC1=C2C(C[C@@H]3NC([C@@H](NC(C4=CSC([C@H](NC(CN(C(C(NC([C@H](NC(CNC3=O)=O)C)=O)=C)=O)C)=O)CO)=N4)=O)CC5=CNC6=CC=CC=C56)=O)=CNC2=CC=C1
Molecular Formula
C40H44N10O9S
Molecular Weight
840.90
References & Citations
[1]Chen X, et al. Therapeutic effects of Argyrin F in pancreatic adenocarcinoma. Cancer Lett. 2017 Jul 28;399:20-28.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
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