Argyrin A
Argyrin A, a cyclical peptide, is a potent antitumoral agent. Argyrin A exerts its effects through a potent inhibition of the proteasome. Argyrin A leads to increased endogenous p27kip1 levels by preventing protein turnover[1].
Product Specifications
CAS Number
174423-37-1
UNSPSC
12352005
Target
Proteasome
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
COC1=C2C(C[C@@H]3NC([C@@H](NC(C4=CSC([C@H](NC(CN(C(C(NC([C@H](NC(CNC3=O)=O)C)=O)=C)=O)C)=O)C)=N4)=O)CC5=CNC6=CC=CC=C56)=O)=CNC2=CC=C1
Molecular Formula
C40H44N10O8S
Molecular Weight
824.90
References & Citations
[1]Nickeleit I, et al. Argyrin a reveals a critical role for the tumor suppressor protein p27 (kip1) in mediating antitumor activities in response to proteasome inhibition. Cancer Cell. 2008 Jul 8;14 (1) :23-35.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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