Arisostatin A

Arisostatin A, a microbial secondary metabolite, is an antibiotic against Gram-positive bacteria and shown to possess potent anti-tumor properties. Arisostatin A induces apoptosis through the activation of caspase-3 and reactive oxygen species (ROS) generation in AMC-HN-4 cells[1].

Product Specifications

CAS Number

[271574-41-5]

UNSPSC

12352005

Target

Antibiotic; Apoptosis; Bacterial

Related Pathways

Anti-infection; Apoptosis

Field of Research

Cancer; Infection

Smiles

[H][C@@]12[C@@](OC3=O)(CC(C=O)=C[C@@H]2O)C(O)=C3C([C@@]4(C)[C@]([H])([C@@H](C)C[C@H](C)[C@@H]5O[C@H]6C[C@@H](O[C@H]7CC[C@@H](O[C@@H]8C[C@@H](O)[C@@H](O[C@H]9CC[C@@H](O)[C@H](C)O9)[C@H](C)O8)[C@H](C)O7)[C@@H](OC(C(C)C)=O)[C@H](C)O6)[C@]5([H])C=C[C@@]4([H])/C(C)=C/C[C@H](O[C@H]%10C[C@@]([N+]([O-])=O)(C)[C@@H](NC(OC)=O)[C@@H](C)O%10)/C(C)=C/1)=O

Molecular Formula

C69H100N2O24

Molecular Weight

1341.53

References & Citations

[1]Kim YH, et al. Arisostatins A induces apoptosis through the activation of caspase-3 and reactive oxygen species generation in AMC-HN-4 cells. Biochem Biophys Res Commun. 2003 Sep 19;309 (2) :449-56.