Amythiamicin D

Amythiamicin D is a thiopeptide antibiotic that inhibits the growth of many Gram-positive bacteria, but not Gram-negative bacteria such as E.coli[1].

Product Specifications

CAS Number

[156620-46-1]

UNSPSC

12352005

Target

Antibiotic; Bacterial

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

O=C1C2=CSC(C3=CC=C(C4=NC(C(OC)=O)=CS4)N=C3C5=CSC(C6=CSC([C@@H](NC(CNC(C7=CSC([C@@H](NC(C8=C(C)SC([C@@H](N1)CC(NC)=O)=N8)=O)C(C)C)=N7)=O)=O)C(C)C)=N6)=N5)=N2

Molecular Formula

C43H42N12O7S6

Molecular Weight

1031.26

References & Citations

[1]Gross S, et al. Amythiamicin D and related thiopeptides as inhibitors of the bacterial elongation factor EF-Tu: modification of the amino acid at carbon atom C2 of ring C dramatically influences activity. ChemMedChem. 2013 Dec;8 (12) :1954-62.