Centaurein

Centaurein, a flavonoid, is an IFN-γ promoter enhancer. Centaurein up-regulates the activity of NFAT and NF-κB enhancers. Centaurein increases the IFN-γ expression in T and NK cells and the serum IFN-γ level in mice. Centaureidin completely relaxes the contractions in intact rat aortic rings. Centaurein effectively protects mice against Listeria infection[1][2][3][4].

Product Specifications

CAS Number

[35595-03-0]

UNSPSC

12352005

Target

Bacterial; IFNAR; NF-κB; Nuclear Factor of activated T Cells (NFAT)

Related Pathways

Anti-infection; Immunology/Inflammation; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Smiles

O=C1C2=C(O)C(OC)=C(O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO)C=C2OC(C4=CC(O)=C(C=C4)OC)=C1OC

Molecular Formula

C24H26O13

Molecular Weight

522.46

References & Citations

[1]Chang SL, et al. Flavonoids, centaurein and centaureidin, from Bidens pilosa, stimulate IFN-gamma expression. J Ethnopharmacol. 2007 Jun 13;112 (2) :232-6. |[2]Chang SL, Yeh HH, Lin YS, Chiang YM, Wu TK, Yang WC. The effect of centaurein on interferon-gamma expression and Listeria infection in mice. Toxicol Appl Pharmacol. 2007 Feb 15;219 (1) :54-61. |[3]Nikiema WA, et al. Systematic Review of Chemical Compounds with Immunomodulatory Action Isolated from African Medicinal Plants. Molecules. 2024 Apr 26;29 (9) :2010. |[4]Orallo F, et al. Preliminary study of the potential vasodilator effects on rat aorta of centaurein and centaureidin, two flavonoids from Centaurea corcubionensis. Planta Med. 1998 Mar;64 (2) :116-9.