Apicularen B

Apicularen B is a V-ATPase inhibitor and cytotoxic macrolide that can be obtained from the myxobacterium Archangium gephyra. Apicularen B can be used in the study of V-ATPase-related diseases, such as osteopetrosis[1][2].

Product Specifications

CAS Number

[220757-06-2]

UNSPSC

12352005

Target

Proton Pump

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Solubility

10 mM in DMSO

Smiles

O=C(O[C@H]1C/C=C/NC(/C=C\C=C/CC)=O)C(C(C[C@@](O[C@@]2([H])C1)([H])C[C@H](C2)O[C@H](O[C@@H]3CO)[C@@H]([C@H]([C@@H]3O)O)NC(C)=O)=CC=C4)=C4O

Molecular Formula

C33H44N2O11

Molecular Weight

644.71

References & Citations

[1]Köteles I, et al. Synthesis of Potential Haptens with Morphine Skeleton and Determination of Protonation Constants. Molecules. 2020 Sep 2;25 (17) :4009.|[2]Hong J, et al. Inhibition of vacuolar-type (H+) -ATPase by the cytostatic macrolide apicularen A and its role in apicularen A-induced apoptosis in RAW 264.7 cells. FEBS Lett. 2006 May 15;580 (11) :2723-30.