Apicularen B
Apicularen B is a V-ATPase inhibitor and cytotoxic macrolide that can be obtained from the myxobacterium Archangium gephyra. Apicularen B can be used in the study of V-ATPase-related diseases, such as osteopetrosis[1][2].
Product Specifications
CAS Number
220757-06-2
UNSPSC
12352005
Target
Proton Pump
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Solubility
10 mM in DMSO
Smiles
O=C(O[C@H]1C/C=C/NC(/C=C\C=C/CC)=O)C(C(C[C@@](O[C@@]2([H])C1)([H])C[C@H](C2)O[C@H](O[C@@H]3CO)[C@@H]([C@H]([C@@H]3O)O)NC(C)=O)=CC=C4)=C4O
Molecular Formula
C33H44N2O11
Molecular Weight
644.71
References & Citations
[1]Köteles I, et al. Synthesis of Potential Haptens with Morphine Skeleton and Determination of Protonation Constants. Molecules. 2020 Sep 2;25 (17) :4009.|[2]Hong J, et al. Inhibition of vacuolar-type (H+) -ATPase by the cytostatic macrolide apicularen A and its role in apicularen A-induced apoptosis in RAW 264.7 cells. FEBS Lett. 2006 May 15;580 (11) :2723-30.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
TA371498 100 µL
Adenosine A2b Receptor (ADORA2B) Rabbit Polyclonal Antibody
Sign In for Pricing
View Details 
PDMH100085-02 100 µg
Recombinant Human EGFR/ErbB1 protein (His tag)
Sign In for Pricing
View Details PDMH100085-03 500 µg
Recombinant Human EGFR/ErbB1 protein (His tag)
Sign In for Pricing
View Details