Ohchinolide B

Ohchinolide B is a tubulin inhibitor. Ohchinolide B inhibits microtubule polymerization (IC50=2.3 μM) and induces G2/M phase cell cycle arrest via mitochondrial apoptotic pathways. Ohchinolide B is promising for research of solid tumors (e.g., breast, lung cancer) [1].

Product Specifications

CAS Number

[71902-49-3]

UNSPSC

12352005

Target

Microtubule/Tubulin

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

C[C@]12[C@@]3([H])[C@](OC[C@@]3([C@@H](C[C@@H]2OC(C)=O)OC(C)=O)C)([H])[C@H]([C@@]4([C@]1([H])CC(O[C@]5([H])C4=C([C@H](C6=COC=C6)C5)C)=O)C)OC(/C(C)=C/C)=O

Molecular Formula

C35H44O10

Molecular Weight

624.72

References & Citations

[1]Ochi M, et al. The structures of ohchinolide A and B, two new limonoids from Melia azedarach Linn. var. japonica Makino[J]. Chemistry Letters, 1979, 8 (9) : 1137-1140.