Isonanangenine B
Isonanangenine B (SF002-96-1) is a selective survivin inhibitor (IC50=1.6 µM) . Isonanangenine B blocks the binding of key transcription factors, such as Stat3 and NF-κB, to the survivin promoter. Isonanangenine B is promising for research of cancers[1][2].
Product Specifications
CAS Number
1623153-14-9
Product Name Alternative
SF002-96-1
UNSPSC
12352005
Target
Survivin
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
C[C@]12[C@@](C(C)(CC[C@H]2O)C)([H])[C@@H](C=C3[C@@]1(COC3=O)O)OC(CCCCC)=O
Molecular Formula
C21H32O6
Molecular Weight
380.48
References & Citations
[1]Lacey HJ, et al. Nanangenines: drimane sesquiterpenoids as the dominant metabolite cohort of a novel Australian fungus, Aspergillus nanangensis. Beilstein J Org Chem. 2019 Nov 5;15:2631-2643.|[2]Felix S, et al. SF002-96-1, a new drimane sesquiterpene lactone from an Aspergillus species, inhibits survivin expression. Beilstein J Org Chem. 2013 Dec 13;9:2866-76.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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