8-Deoxylactucin

8-Deoxylactucin is an orally active sesquiterpene lactone. 8-Deoxylactucin inhibits LPS (HY-D1056) -induced NO production in RAW264.7 macrophages with an IC50 value of 4.35 μM. 8-Deoxylactucin exerts anti-inflammatory effects by blocking the NF-κB pathway. 8-Deoxylactucin demonstrates hepatoprotective efficacy in LPS/D-galactosamine-induced acute hepatitis model of mice. 8-Deoxylactucin can be used for the study of inflammatory diseases and inflammatory liver injuries[1].

Product Specifications

CAS Number

[65725-10-2]

UNSPSC

12352005

Target

NF-κB; NO Synthase; Reactive Oxygen Species (ROS)

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Inflammation/Immunology

Smiles

OCC([C@]1([H])[C@]2([H])[C@](CCC(C)=C13)([H])C(C(O2)=O)=C)=CC3=O

Molecular Formula

C15H16O4

Molecular Weight

260.29

References & Citations

[1]Zhou Y, et al. Sesquiterpene lactones from Cichorium intybus exhibit potent anti-inflammatory and hepatoprotective effects by repression of NF-κB and enhancement of NRF2. J Ethnopharmacol. 2025 Mar 13;343:119439.