Sigmoidin B
Sigmoidin B, a prenylated flavanone, is a selective 5-lipoxygenase inhibitor. Sigmoidin B is a potent scavenger of the DPPH radical. Sigmoidin B has antigenotoxic activity that inhibits genotoxicity induced by Aflatoxin B1 , with an IC50 of 18.7 μg/mL. Sigmoidin B has anti-inflammatory activity and antioxidant properties[1][2].
Product Specifications
CAS Number
87746-47-2
UNSPSC
12352005
Target
Lipoxygenase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease; Inflammation/Immunology
Smiles
O=C1C2=C(O)C=C(O)C=C2O[C@H](C3=CC(C/C=C(C)\C)=C(C(O)=C3)O)C1
Molecular Formula
C20H20O6
Molecular Weight
356.37
References & Citations
[1]Zarev Y, et al. Antigenotoxic prenylated flavonoids from stem bark of Erythrina latissima. Phytochemistry. 2017 Sep;141:140-146. |[2]Njamen D, et al. Anti-inflammatory activities of two flavanones, sigmoidin A and sigmoidin B, from Erythrina sigmoidea. Planta Med. 2004 Feb;70 (2) :104-7.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
5-LOX
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