Sigmoidin B

Sigmoidin B, a prenylated flavanone, is a selective 5-lipoxygenase inhibitor. Sigmoidin B is a potent scavenger of the DPPH radical. Sigmoidin B has antigenotoxic activity that inhibits genotoxicity induced by Aflatoxin B1 (HY-N6615), with an IC50 of 18.7 μg/mL. Sigmoidin B has anti-inflammatory activity and antioxidant properties[1][2].

Product Specifications

CAS Number

[87746-47-2]

UNSPSC

12352005

Target

Lipoxygenase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease; Inflammation/Immunology

Smiles

O=C1C2=C(O)C=C(O)C=C2O[C@H](C3=CC(C/C=C(C)\C)=C(C(O)=C3)O)C1

Molecular Formula

C20H20O6

Molecular Weight

356.37

References & Citations

[1]Zarev Y, et al. Antigenotoxic prenylated flavonoids from stem bark of Erythrina latissima. Phytochemistry. 2017 Sep;141:140-146. |[2]Njamen D, et al. Anti-inflammatory activities of two flavanones, sigmoidin A and sigmoidin B, from Erythrina sigmoidea. Planta Med. 2004 Feb;70 (2) :104-7.