Triptolidenol
Triptolidenol, a traditional Chinese medicine, is an epoxy diterpene lactone that can be isolated from Tripterygium wilfordii. Triptolidenol has anti-inflammatory and anticancer activities. Triptolidenol significantly inhibits tumor cell proliferation and migration, arrests cell cycle arrest at S phase and induces apoptosis by activating the cytochrome c/caspase cascade signaling pathway. Triptolidenol disrupts NF-κB/COX-2 pathway by inhibiting IKKβ at ATP-binding sites. Triptolidenol can be used for chronic nephritis and kidney cancer like clear cell renal cell carcinoma (ccRCC) research[1].
Product Specifications
CAS Number
99694-86-7
UNSPSC
12352005
Target
Apoptosis; Caspase; COX; IKK; NF-κB
Related Pathways
Apoptosis; Immunology/Inflammation; NF-κB
Field of Research
Cancer; Inflammation/Immunology
Smiles
C[C@@]12[C@@]34[C@]5([C@@H]([C@@]6([C@](O6)([H])[C@]3([H])O4)C(C)(O)C)O)[C@@](C[C@@]1([H])C7=C(C(OC7)=O)CC2)([H])O5
Molecular Formula
C20H24O7
Molecular Weight
376.40
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
COX-2; IKK-β; RelA/p65
Frequently Asked Questions
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