Triptolidenol

Triptolidenol, a traditional Chinese medicine, is an epoxy diterpene lactone that can be isolated from Tripterygium wilfordii. Triptolidenol has anti-inflammatory and anticancer activities. Triptolidenol significantly inhibits tumor cell proliferation and migration, arrests cell cycle arrest at S phase and induces apoptosis by activating the cytochrome c/caspase cascade signaling pathway. Triptolidenol disrupts NF-κB/COX-2 pathway by inhibiting IKKβ at ATP-binding sites. Triptolidenol can be used for chronic nephritis and kidney cancer like clear cell renal cell carcinoma (ccRCC) research[1].

Product Specifications

CAS Number

[99694-86-7]

UNSPSC

12352005

Target

Apoptosis; Caspase; COX; IKK; NF-κB

Related Pathways

Apoptosis; Immunology/Inflammation; NF-κB

Field of Research

Cancer; Inflammation/Immunology

Smiles

C[C@@]12[C@@]34[C@]5([C@@H]([C@@]6([C@](O6)([H])[C@]3([H])O4)C(C)(O)C)O)[C@@](C[C@@]1([H])C7=C(C(OC7)=O)CC2)([H])O5

Molecular Formula

C20H24O7

Molecular Weight

376.40

References & Citations

[1]Jin J, et al. Triptolidenol, isolated from Tripterygium wilfordii, disrupted NF-κB/COX-2 pathway by targeting ATP-binding sites of IKKβ in clear cell renal cell carcinoma. Fitoterapia. 2021 Jan;148:104779.