Tetrahydroalstonine

Tetrahydroalstonine ((-) -Tetrahydroalstonine) is an indole alkaloid and a selective α₂-adrenergic receptor antagonist. Tetrahydroalstonine exhibits certain neuroprotective effects. Tetrahydroalstonine can regulate autophagy-lysosomal function by activating the Akt/mTOR pathway, significantly reducing OGD/R-induced primary cortical neuronal injury[1][2][3].

Product Specifications

CAS Number

[6474-90-4]

Product Name Alternative

(-) -Tetrahydroalstonine

UNSPSC

12352005

Hazard Statement

H302, H312

Target

Adrenergic Receptor; Akt; Atg8/LC3; mTOR

Related Pathways

Autophagy; GPCR/G Protein; Neuronal Signaling; PI3K/Akt/mTOR

Applications

Neuroscience-Neuromodulation

Field of Research

Endocrinology; Neurological Disease

Purity

99.84

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(OC)C1=CO[C@@H](C)[C@@]2([H])[C@]1([H])C[C@@]3([H])C4=C(C5=CC=CC=C5N4)CCN3C2

Molecular Formula

C21H24N2O3

Molecular Weight

352.43

Precautions

H302, H312

References & Citations

[1]Malik S, et al. Tetrahydroalstonine from Fruits of Rhazya stricta. Planta Med. 1984 Jun;50 (3) :283.|[2]Roquebert J, et al. Inhibition of the alpha 1 and alpha 2-adrenoceptor-mediated pressor response in pithed rats by raubasine, tetrahydroalstonine and akuammigine. Eur J Pharmacol. 1984 Oct 30;106 (1) :203-5.https://www.ncbi.nlm.nih.gov/pubmed/6099269|[3]Liao Y, et al. The Protective Effect of (-) -Tetrahydroalstonine against OGD/R-Induced Neuronal Injury via Autophagy Regulation. Molecules. 2023 Mar 4;28 (5) :2370.