Tetrahydroamentoflavone

Tetrahydroamentoflavone (Amentoflavanone) is a potent xanthine oxidase (XO) inhibitor. Tetrahydroamentoflavone has inhibitory activity for XO with IC50 and Ki values of 92 nM and 0.982 μM, respectively. Tetrahydroamentoflavone can be used for the research of inflammatory disorders and gout[1].

Product Specifications

CAS Number

[48236-96-0]

Product Name Alternative

Amentoflavanone

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

Xanthine Oxidase

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Solubility

10 mM in DMSO

Smiles

OC1=CC(O)=C(C(C[C@@H](C2=CC=C(C=C2)O)O3)=O)C3=C1C4=CC([C@H]5OC6=CC(O)=CC(O)=C6C(C5)=O)=CC=C4O

Molecular Formula

C30H22O10

Molecular Weight

542.49

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

References & Citations

[1]Ranjith Arimboor, et al. Tetrahydroamentoflavone (THA) from Semecarpus anacardium as a potent inhibitor of xanthine oxidase. J Ethnopharmacol. 2011 Feb 16;133 (3) :1117-20.