(-) -Codonopsine

(-) -Codonopsine is an alkaloid that can be found in Codonopsis clematidea. It has antibacterial and hypotensive activities. The MIC value of (-) -Codonopsine against Escherichia coli (E. coli) is 64 μg/mL. (-) -Codonopsine is expected to be used in the research of anti-infection and cardiovascular fields[1][2].

Product Specifications

CAS Number

[26989-20-8]

UNSPSC

12352005

Target

Bacterial

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Cardiovascular Disease

Smiles

O[C@@H]1[C@H](N([C@@H]([C@H]1O)C)C)C2=CC(OC)=C(C=C2)OC

Molecular Formula

C14H21NO4

Molecular Weight

267.32

References & Citations

[1]Iida H, et al. Stereochemical revision and absolute configuration of codonopsinine[J]. Tetrahedron letters, 1986, 27 (44) : 5393-5396.|[2]El-Nezhawy AOH, et al. Design and total synthesis of (-) -codonopsinine, (-) -codonopsine and codonopsinine analogues by O- (2-oxopyrrolidin-5-yl) trichloroacetimidate as amidoalkylating agent with improved antimicrobial activity via solid lipid nanoparticle formulations. Bioorg Med Chem. 2019 Apr 1;27 (7) :1263-1273.