Disialyllacto-N-tetraose

Disialyllacto-N-tetraose is a human milk oligosaccharide that prevents necrotising enterocolitis in neonatal rats[1].

Product Specifications

CAS Number

[61278-38-4]

UNSPSC

12352005

Target

Endogenous Metabolite

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Purity

98.50

Solubility

10 mM in DMSO

Smiles

OC([C@@]1(O[C@@]([C@@H]([C@H](C1)O)NC(C)=O)([H])[C@H](O)[C@H](O)CO)O[C@@H]2[C@H]([C@@H](O[C@@H]([C@@H]2O)CO)O[C@@H]3[C@H]([C@@H](O[C@@H]([C@H]3O)CO[C@]4(O[C@@]([C@@H]([C@H](C4)O)NC(C)=O)([H])[C@H](O)[C@H](O)CO)C(O)=O)O[C@@H]5[C@H]([C@@H](O[C@@H]([C@@H]5O)CO)O[C@H]([C@H](O)CO)[C@H](O)[C@@H](O)C=O)O)NC(C)=O)O)=O

Molecular Formula

C48H79N3O37

Molecular Weight

1290.14

References & Citations

[1]Jantscher-Krenn E, et al. The human milk oligosaccharide disialyllacto-N-tetraose prevents necrotising enterocolitis in neonatal rats. Gut. 2012 Oct;61 (10) :1417-25.|[2]Zhang W, et al. The protective effects of disialyllacto-N-tetraose of neonatal intestinal barriers in the prevention of necrotizing enterocolitis[J]. Chinese Journal of Neonatology, 2022: 350-355.|[3]Zhang W, et al., Causative role of mast cell and mast cell-regulatory function of disialyllacto-N-tetraose in necrotizing enterocolitis. Int Immunopharmacol. 2021 Jul;96:107597.