α-Turmerone

α-turmerone is a turmerone. α-turmerone can be isolated from Curcuma longa. α-turmerone decreases the expression of cyclin D1, pro-caspases-3 and -8 and down-regulates Bcl-2 expression. α-turmerone causes mitochondrial transmembrane depolarization. α-turmerone induces Apoptosis. α-turmerone has immunostimulatory effects. α-turmerone has anti-cancer activity against liver cancer and breast cancer[1].

Product Specifications

CAS Number

[82508-15-4]

UNSPSC

12352211

Target

Apoptosis; Bcl-2 Family; Caspase; CDK; Mitochondrial Metabolism

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Field of Research

Cancer; Inflammation/Immunology

Smiles

C/C(C)=C\C(CC(C1C=CC(C)=CC1)C)=O

Molecular Formula

C15H22O

Molecular Weight

218.33

References & Citations

[1]Yue GG, et al. Evaluation of in vitro anti-proliferative and immunomodulatory activities of compounds isolated from Curcuma longa. Food Chem Toxicol. 2010 Aug-Sep;48 (8-9) :2011-20.