α-Turmerone
α-turmerone is a turmerone. α-turmerone can be isolated from Curcuma longa. α-turmerone decreases the expression of cyclin D1, pro-caspases-3 and -8 and down-regulates Bcl-2 expression. α-turmerone causes mitochondrial transmembrane depolarization. α-turmerone induces Apoptosis. α-turmerone has immunostimulatory effects. α-turmerone has anti-cancer activity against liver cancer and breast cancer[1].
Product Specifications
CAS Number
82508-15-4
UNSPSC
12352211
Target
Apoptosis; Bcl-2 Family; Caspase; CDK; Mitochondrial Metabolism
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Field of Research
Cancer; Inflammation/Immunology
Smiles
C/C(C)=C\C(CC(C1C=CC(C)=CC1)C)=O
Molecular Formula
C15H22O
Molecular Weight
218.33
References & Citations
[1]Yue GG, et al. Evaluation of in vitro anti-proliferative and immunomodulatory activities of compounds isolated from Curcuma longa. Food Chem Toxicol. 2010 Aug-Sep;48 (8-9) :2011-20.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Bcl-2; Caspase 3; Caspase 8
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