Galegine (hemisulfate)

Galegine hemisulfate, a guanidine derivative, contributes to weight loss in mice. Galegine hemisulfate activates AMPK in 3T3-L1 adipocytes and L6 myotubes, as well as in the H4IIE rat hepatoma and HEK293 human kidney cell lines. Galegine hemisulfate has antibacterial activity, with minimum inhibitory concentration of 4 mg/L against Staphylococcus aureus strains[1][2].

Product Specifications

CAS Number

[14279-86-8]

UNSPSC

12352211

Hazard Statement

H301, H315, H319, H335

Target

AMPK; Bacterial

Related Pathways

Anti-infection; Epigenetics; PI3K/Akt/mTOR

Field of Research

Infection; Metabolic Disease

Purity

99.70

Solubility

H2O : 40 mg/mL (ultrasonic)

Smiles

NC(NC/C=C(C)\C)=N.OS(O)(=O)=O.[1/2]

Molecular Formula

C6H13N3.1/2H2O4S

Molecular Weight

176.23

Precautions

H301, H315, H319, H335

References & Citations

[1]Mooney MH, et al. Mechanisms underlying the metabolic actions of galegine that contribute to weight loss in mice. Br J Pharmacol. 2008 Apr;153 (8) :1669-77.|[2]Coqueiro A, et al. In Vitro Antibacterial Activity of Prenylated Guanidine Alkaloids from Pterogyne nitens and Synthetic Analogues. J Nat Prod. 2014 Aug 22;77 (8) :1972-5.