Arenobufagin (Standard)
Arenobufagin is a natural bufadienolide that can be extracted from toad venom. Arenobufagin can induce apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway. Arenobufagin has potent antineoplastic activity against HCC HepG2 cells as well as corresponding multidrug-resistant HepG2/ADM cells. Arenobufagin can inhibit VEGF-mediated angiogenesis through suppression of VEGFR-2 signaling pathway[1][2].
Product Specifications
CAS Number
464-74-4
UNSPSC
12352005
Target
Akt; Apoptosis; Atg8/LC3; Autophagy; Caspase; mTOR; PARP; PI3K
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
C[C@]([C@@H](C(C=C1)=COC1=O)CC2)(C3=O)[C@]2([C@@](CC[C@@]4([H])[C@@]5(CC[C@H](O)C4)C)([H])[C@]5([H])[C@@H]3O)O
Molecular Formula
C24H32O6
Molecular Weight
416.51
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Frequently Asked Questions
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